Introduction: SARS-CoV-2 infection is characterized by proinflammatory state and excessive cytokine production, which are accompanied by increased level of oxidative stress. The study was performed in order to investigate the impact of body weight on oxidative stress markers in COVID-19 patients.
Methods: A total of 30 patients infected with SARS-CoV-2 were included in the study and they were divided in two groups according to their BMI – normal and overweight. Blood samples were taken for routine laboratory analysis (differential blood count, ferritin, cholesterol, triglycerides, bilirubin, urea, creatinine, glucose, ALT, AST, LDH, CK, iron, CRP, D-dimer), as well as for measurement of oxidative stress parameters and inflammation markers on admission. FRAS5 analytical photometric system was applied for measurement of oxidative stress parameters (d-ROM, PAT, OS index).
Results: The majority of overweight patients had underlying medical conditions at admission. The most frequently reported comorbidities were hypertension, diabetes and chronic cardiac disease. This group had increased levels of d-ROMs (free radicals) and oxidative stress index (OSI) in comparison to the patients with normal weight (p<0.05). The values of PAT (total antioxidant capacity) did not differ significantly between both study groups (p>0.05). Additionally, the overweight patients had longer duration of symptoms and increased values of CRP, D-dimer, IL-6 and LDH compared to the normal group (p<0.05).
Conclusion: This study shows that the overweight patients had higher levels of oxidative stress compared the patients with normal weight. Additionally, these patients had more severe clinical symptoms accompanied by increased levels of selected laboratory parameters (CRP, D-dimer, LDH, IL-6). Lowering of increased BMI could contribute to faster recovery during SARS-CoV-2 infection.
What will audience learn from your presentation?
- Impact of obesity on the clinical symptoms of COVID-19
- Potential of oxidative stress parameters measurement as a predictor tool of disease complication
- Lowering of increased BMI could contribute to faster recovery during SARS-CoV-2 infection.