Abstract:
Background: The aim of the present study was to assess the effects of a hyperlipidic diet set before puberty in male Wistar rats’ gonadal weights and testicular functions.
Methods: Males rats were used for the study, they were randomly distributed into 2 groups: Control Group (CG: standard diet (normolipidemic) and Intervention Group (IG: hyperlipidemic diet), after 7 days of experimentation, 3 rats were sacrificed per week, blood samples were collected and HDL, LDL levels and triglyceride were analyzed.
Results: triglyceride and HDL levels showed a consistent change over the weeks of the study. Photomicraphie of the testicles of Wistar rats in the hyperlipid diet group for the first week showed Sertoli cell hyperplasia , during the second week we showed significant testicular hypertrophy and in the fifth week hyperplasia of the seminal vesicle characterized by an increase in the number of glandular epithelial cells is showed. The proliferating epithelium may form papillary structures with supporting stroma and with extension into the glandular lumen and total absence of sperm cells.
Conclusion: The implication of obesity or at least an adipose excess on there productive function is no longer a doubts. The deleterious effects of lipid accumulation manifest themselves in the neuro-endocrial regulation system, which will induce a physiological adaptation and will pass on peripheral effects, particularly through the control of gonadotropins. There will also be direct effects on the gonads, accentuating the central disorders.
