Abstract:
This literature review focuses on patients with congenital leptin deficiency who had never been exposed to endogenous or exogenous leptin and its effect on energy intake, body weight, body fat mass percentage, genetic leptin deficiency phenotype, serum levels of leptin, metabolic and hormonal parameters ( lipids profile, blood sugar parameters and gonadotropic hormones). Most available data on leptin replacement therapy were cross over studies. The aim of this review is to identify patients with genetic leptin deficiency, its phenotypes and to explore leptin replacement therapy among individuals who are only naïve for leptin. The review demonstrated that leptin replacement therapy has powerful effects and its phenotypes are almost reversible, and that affected cases are under estimated.
Biography:
Dr.Aalaa has obtained her primary medical degree from University of Khartoum, Khartoum, Sudan in 2006. She did her primary medical clinical training in Khartoum, Sudan under supervision of Federal Ministry of Health. She worked as a transplant co- coordinator (2009-2010) and participated in a case report ‘Castle man disease’ published in Arab Journal of Nephrology and transplantation 2011. She finished her MSc of Science in Obesity and Weight Management in 2018 from University of South Wales, Wales, United Kingdom and MSc of Science in Endocrinology and Diabetes in 2023 from Queen Mary University of London, London, United Kingdom. Published an article, title: “A review on congenital leptin deficiency: Phenotypes, diagnosis and management” in Journal of Obesity and Weight Loss Therapy in March 2021. Conducted a research, title: “A literature review: Management of type 1 diabetes mellitus beyond insulin” to be published in the coming period Currently works as an endocrinology and diabetes resident in endocrinology and diabetes center in Hafer Al Batin city, Saudi Arabia. In charge of insulin pump outpatient clinic 2023-2024. Writer of clinical medical questions in endocrinology and diabetes to those who are subscribers with Learna@StudyPRN 2021-2022.
