Title : Effects of Weight Loss and Beneficial on Insulin Secretion and Sensitivity in Obese Type 2 Diabetes Mellitus Patients from Subsaharan Africa Origin
Background: This study is aimed at evaluating the effect of weight loss on glycaemic, lipid profile, insulin secretion and insulin sensitivity in obese, T2DM patients.
Methods: We carried out a non-randomized single-arm clinical trial at the National Obesity Centre of the Yaounde Central Hospital. The study population consisted of 20 obese T2DM patients. They were all placed on a hypocaloric-hypolipidemic regimen over a six-week period. Glycemic profile, insulin sensitivity and insulin secretion using the 2h-Oral Glucose Tolerance Test were assessed before and after the intervention. In addition, follow-up visits were done every week to assess weight loss patterns and record complaints from participants.
Results: Twenty (20) participants were enrolled (14 females and 6 males) with a median age of 56 (25-75) years, diabetes duration of at least 2 years and a median BMI of 34.03 Kg/m2. Out of the 20 participants, 10 were on insulin and 15 on biguanide. After the intervention, we observed a significant improvement in insulin secretion evaluated using the AUC of serum C-peptide concentration from 0.8 (0.6-1.1) nmol/l/120 minutes before the intervention to 1.8 (1.4-2.1) nmol/l/120 minutes after (p<0.01). Also, insulin sensitivity assessed using QUICKI improved from 0.56 (0.49-0.59) before the intervention to 0.60 (0.54-0.63) after (p= 0.015) after caloric restriction.
Conclusion: Diet control in obese, type 2 diabetes mellitus patients induces a 5.0 ±1% weight loss with beneficial effects on glycaemic and lipid profile, insulin secretion and insulin sensitivity.
What will audience learn from your presentation?
- The impact of a short time hypocaloric-hypolipidemic regimen on weight loss
- The impact of weight loss following short time hypocaloric-hypolipidemic regimen on the improvement of insulin secrection and insulin sensitivity
- The impact of weight loss following short time hypocaloric-hypolipidemic regimen on beta cell function