Postprandial thermogenesis, the energy expenditure following a meal, plays a role in obesity as it influences the body’s calorie-burning efficiency. In individuals with obesity, this thermogenic response can be lower, contributing to reduced calorie expenditure and weight gain. Foods with high protein content or certain spices, like chili peppers, can enhance postprandial thermogenesis, aiding in weight management by increasing the calories burned after eating. By optimizing postprandial thermogenesis through dietary choices, individuals with obesity may achieve better energy balance, making it a valuable target in weight loss strategies aimed at enhancing natural calorie-burning mechanisms.