Excess body weight significantly impacts joint health, making osteoarthritis, chronic pain & musculoskeletal issues in obesity major concerns for long-term mobility and quality of life. Increased mechanical stress on weight-bearing joints accelerates cartilage degradation, leading to osteoarthritis progression, particularly in the knees and hips. Additionally, systemic inflammation associated with obesity contributes to joint pain and musculoskeletal disorders beyond just mechanical strain. Chronic pain further limits physical activity, creating a cycle of weight gain and reduced mobility. Effective management strategies involve weight reduction, targeted physical therapy, and anti-inflammatory dietary approaches to alleviate symptoms and improve joint function. Emerging treatments, including regenerative medicine and biologic therapies, are being explored to address obesity-related musculoskeletal complications more effectively.