The complexity of obesity necessitates tailored approaches, making precision medicine & personalized treatment plans for obesity an emerging focus in medical research. Genetic predisposition, metabolic profiles, and gut microbiome composition vary among individuals, influencing responses to different weight loss interventions. Advances in genetic testing and biomarker analysis enable the identification of obesity subtypes, allowing for customized dietary and pharmacological strategies. Personalized weight management plans consider factors such as hormonal imbalances, psychological determinants, and lifestyle habits to improve treatment efficacy. Artificial intelligence and machine learning are further refining obesity treatment by predicting individual responses to various interventions. The shift toward precision medicine aims to enhance long-term success rates, moving beyond one-size-fits-all approaches to deliver targeted, effective obesity care.