Sustaining long-term weight loss is often more challenging than initial weight reduction, making weight maintenance strategies & prevention of weight regain essential components of obesity management. Physiological adaptations, such as decreased metabolic rate and increased hunger hormones, often contribute to rebound weight gain. Behavioral factors, including emotional eating, lack of physical activity, and social influences, further complicate maintenance efforts. Sustainable strategies focus on habit formation, mindful eating, and consistent exercise routines tailored to individual preferences. Regular self-monitoring, including food tracking and weight check-ins, enhances adherence. Emerging research suggests that personalized nutrition, gut microbiota modulation, and pharmacological support can play roles in maintaining weight stability. A multidisciplinary approach integrating behavioral counseling, dietary modifications, and long-term lifestyle changes is crucial for preventing weight regain and ensuring lasting health benefits.