Metabolic adaptation is the body’s response to caloric restriction, which often occurs during weight loss. When the body detects a calorie deficit, it adjusts by reducing the resting metabolic rate to conserve energy, a phenomenon known as adaptive thermogenesis. This adaptation can make further weight loss difficult as the body burns fewer calories, even at rest. To overcome this, incorporating intermittent caloric adjustments or mixing exercise types can help maintain a higher metabolic rate. Understanding metabolic adaptation is essential for obesity management, as it enables a strategic approach to weight loss, preventing plateaus, and supporting sustained, long-term weight reduction in individuals with obesity.