Low-calorie sweeteners (LCS) are commonly used as alternatives to sugar to reduce calorie intake and support weight loss. These sweeteners, such as aspartame, stevia, and sucralose, provide sweetness without the added calories of regular sugar, making them an appealing option for those looking to manage their weight. However, research on their long-term effects on obesity is mixed. Some studies suggest that LCS may not significantly aid in weight loss and may even contribute to increased calorie consumption by triggering cravings for sweet, high-calorie foods. Additionally, LCS can alter the gut microbiome, potentially affecting metabolic processes and hunger regulation. While they are generally considered safe for consumption, relying solely on low-calorie sweeteners may not be an effective strategy for obesity management. A balanced approach that focuses on overall dietary habits and lifestyle changes is essential for long-term weight control.