Leptin, a hormone produced by fat cells, regulates hunger and energy expenditure, signaling the brain when the body has sufficient energy. However, in people with obesity, leptin resistance can occur, leading the brain to perceive starvation despite ample energy stores, which drives overeating. Leptin therapy aims to restore this balance by overcoming leptin resistance, thus potentially reducing hunger and aiding in weight loss. While research is still ongoing, leptin therapy represents a promising intervention for those who struggle with hunger regulation. Combining leptin therapy with lifestyle changes could improve outcomes, providing a novel approach to help manage obesity.