Leptin resistance is a hallmark of obesity, characterized by the body's reduced responsiveness to leptin, a hormone produced by fat cells to signal satiety. Although leptin levels increase with body fat, the brain may fail to recognize this signal, encouraging continuous eating and weight gain. This resistance is often linked to chronic inflammation and can be exacerbated by diets high in processed foods and refined sugars. Strategies to combat leptin resistance include adopting an anti-inflammatory diet, increasing physical activity, and focusing on high-nutrient, low-calorie foods. Addressing leptin resistance is essential in obesity treatment, as improved leptin sensitivity can help individuals achieve a healthier weight and maintain it over the long term.