In obesity, fatty acid metabolism is often disrupted, leading to an imbalance between fat storage and fat utilization. The body’s ability to break down and oxidize fatty acids may be impaired, contributing to increased fat accumulation in adipose tissue. This altered metabolic state also affects the liver, where excess fatty acids can be converted into triglycerides, increasing the risk of non-alcoholic fatty liver disease (NAFLD). A key factor in this process is insulin resistance, which further inhibits the breakdown of fat and encourages its storage. Understanding the role of fatty acid metabolism in obesity offers potential avenues for therapeutic interventions, such as drugs targeting fat oxidation, to help manage weight and prevent metabolic diseases.