Obesity can be accompanying with numerous endocrine variations arising as a result of changes in the hypothalamic-pituitary hormones axes. These include hypothyroidism, hypogonadism, Cushing’s disease and growth hormone shortage. Adipose tissue has many other vital functions that can be mediated through hormones or constituents produced and released by adipocytes which comprise leptin and adiponectin. Hypothyroidism is a communal clinical problem seen in obese patients and could subsidize to the presence of symptoms such as weakness and inability to focus. Hypogonadism and growth hormone shortages are both connected with abdominal obesity. The treatment of these two conditions can outcome in improving conditioning, muscle strength, and stamina in weight loss, better-quality metabolic profile, and enhanced bone density.