The neuroendocrine system plays a critical role in appetite regulation, involving interactions between the brain and hormonal signals from the gut and fat tissue. Hormones like ghrelin, leptin, and insulin send signals to the hypothalamus, influencing hunger and energy balance. In obesity, the brain's response to these signals may become dysregulated, leading to increased hunger and reduced satiety. For instance, leptin resistance is common in obesity, where despite high levels of leptin, the brain does not recognize fullness signals effectively. Treatments targeting neuroendocrine pathways are being explored to restore appetite control, making neuroendocrine regulation a promising area for obesity management.