HYBRID EVENT: You can participate in person at Orlando, Florida, USA or Virtually from your home or work.
WOC 2022

Vinod Nikhra

Vinod Nikhra, Speaker at Weight Management Congress
Hindu Rao Hospital, India
Title : The gut microbial dysbiosis and its metabolic and endocrinological fallouts


THE HUMAN GUT MICROBIOSPHERE: The gastro-intestinal tract and various other organs including skin, respiratory tract and lungs, and genitals harbor large and diverse communities of bacteria, viruses, and other microscopic life. In the human gut, a nutrient-rich environment, reside over 100 trillion microbes, the vast majority of which are present in the colon. There inhabit microbial members as residents (autochthonous), while others (allochthonous) are from ingested food, water, and other components of the environment. The adult human gut microbiota is dominated by mainly two bacteria, the Bacteroidetes and Firmicutes, and archaea, Metanobrevibacter smithii. In addition, there exists a bidirectional microbiota–gut–brain communication modulating physiological processes.
GUT ECOSYSTEM AND MICROBIOTA: The gut microbial communities depend on their specific enzymes to utilize available nutrients, cell-surface molecular appendages to attach to their habitat, evade bacteriophages, ably deal with immune system, and avoid washout and genetic mutability to stay well-adapted. The intestinal epithelium actively senses various bacteria and plays an essential role in maintaining host-microbial homeostasis at the mucosal interface. The microbial ecosystem through molecular processes influences various biological processes, and in turn organ physiology and have a bearing on energy metabolism, insulin sensitivity and resistance, and weight gain, development of diabetes, and ageing process.
THE ALTERED MICROBIAL STATES: There is a causal relationship between altered microbial communities, that is, dysbiosis and disease states. In turn, the host factors like unhealthy diet, environmental factors, and use of medications, especially antibiotics, have impact on the gut microbiota composition and function and contribute to gut dysbiosis. On the one hand, the gut microbes harbor enzymes and secrete molecules that can influence drug activation, efficacy, and metabolism. Certain metabolites produced them can potentially alter the immune system’s sensitivity to tumor cells, whereas dysbiosis may lead to the loss of antitumor immunity. The associated extra-intestinal disorders include metabolic diseases, allergic disorders, neuropsychiatric disorders, autoimmune diseases, and neoplasia.

THE MODULATION OF MICROBIOME: Apart from metabolic and endocrinal functions, the gut microbiome appears to play a significant role in age-associated functional decline and physical frailty. The health and healthy aging as a composite encompass not only on genetics, lifestyle choices and a positive attitude, but also the status of gut microbiome. In fact, the disturbed and disbalanced microbiome has been related to various degenerative disease states and accelerated aging. Therapeutically, it may be possible to overcome dysbiosis and reset and restore normal microbiome through dietary and lifestyle modifications, probiotics and prebiotics, logical antibiotic therapy and bariatric surgery, and fecal microbial transplantation

The audience will learn about:
The understanding about microbiota is evolving and presents as an important research avenue.
The microbiota influences various biological processes, and in turn organ physiology and have a bearing on insulin resistance, gastrointestinal processes, and energy metabolism and influence weight gain, development of diabetes, and ageing.
The correction of microbial dysbiosis appears to be an evolving therapeutic tool for treating ailments like obesity, diabetes, various degenerative disorders including neurological, and hold immense research and clinical interest.


Dr. Vinod Nikhra works as Consultant and Division Head Department of Medicine at Hindu Rao Hospital, New Delhi, India.Qualified in internal medicine, he has been trained in cardiology, endocrinology, nephrology, and hospital management. Apart from this his interest areas include aging research, clinical virology, gastroenterology, obesity, and metabolic syndrome. He is reviewer and on editorial board of various international journals. He has published over 100 research and review papers in leading journals, and 12 books and eBooks including ‘Date with the Pandemic’, ‘Ageing slowly, Living longer’, and ‘Anti-Obesity Guide’, which are available on Amazon and its subsidiaries and other book sellers. He has traveled widely and spoken at medical and scientific meetings in various countries.