Abstract:
Background: This study investigates the correlation between different adiposity metrics, such as total body adiposity (measured by Body Mass Index (BMI) and Waist Circumference (WC)). with Insulin, Hepcidin, Ferritin, and glucose. Aim of the study the relationships between Insulin with Hepcidin and Ferritin in obese males.
Patients and methods: Ninety males were enrolled in the research investigation; forty Subjects were recruited for the study investigation. where have BMI 30 kg/m2 or more, and overweight group with twenty subjects were have BMI between 25-30 kg/m2, and another thirty to the control group were have low BMI<25 kg/m2. The serum Hepcidin, serum fasting insulin, serum ferritin and fasting glucose was evaluated in each of studied groups.
Results The Obese group showed significant increase of the serum hepcidin concentration compared with the control group (4.65 ± 1.92 vs. 3.43 ±1.52, p = 0.015). No significant variations were observed among the three groups in terms of ferritin and glucose levels. The correlation coefficient (r) showed that Insulin values in obese group had negative association with ferritin level r= 0.61, indicating a high effect size (p =<.0001, 95 % Confidence interval = [-.78_ -.38]) no other significant correlation was noted in other groups and parameters.
Conclusions: Investigation of iron regulated cytokine hepcidin can be participated in future as iron deficiency marker in obese subject in conjugation with serum iron and serum ferritin.
Keywords: Obesity, Hepcidin, Insulin resistance, Iron deficiency.
