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Tatiana A Korolenko, Speaker at Obesity Conferences
Research Institute of Neurosciences and Medicine, Russian Federation


Db/db mice with obesity (carrying a mutation in the gene encoding leptin receptor) show autophagy suppression. Our aim was to evaluate the effect of autophagy inducer trehalose on liver and heart autophagy in db/db mice and to study inflammation dysregulation and the suitability of chitinases’ expression levels as diabetes markers. The db/db model manifested inflammation symptoms: overexpression of TNF-α in the spleen and under expression of IL-10 in the liver and spleen (cytokine imbalance). Simultaneously, we revealed decreased expression of chitotriosidase (CHIT1) and acid chitinase (CHIA) in the liver of db/db mice. Compared to a control, CHIA expression in db/db mice is significantly lower only in the spleen, indicating different expression changes for these two enzymatically active chitinases. Trehalose treatment of db/db mice was followed by increased autophagy induction in the heart and liver (in addition to autophagy induction in the brain, as shown by us previously). Trehalose exerted the beneficial cardiac effects possibly via increased lipophagy (uptake of lipid droplets). The autophagy activation by trehalose had several positive effects on the heart and liver of db/db mice; therefore, lipophagy activation seems to be a promising therapy for diabetes. We propose some mechanisms for the observed positive influence of trehalose.


Dr. Tatiana A. Korolenko studied Medicine at Novosibirsk Medical University, Russia and graduated as MS in 1965. She then joined the research group of Prof. Yacobson G.S. at the Central Research Laboratoty of Novosibirsk Medical University.  She received her PhD degree in 2004 at the same institution. After  postdoctoral fellowship supervised by Dr Hans Fritz  Munchen, Germany she obtained the position of an Associate Professor at the Research Institute of Physiology, Academy of Medical Sciences of Russia. She has published more than 70 research articles in SCI(E) journals.)