HYBRID EVENT: You can participate in person at Baltimore, Maryland, USA or Virtually from your home or work.
Higinio Mappala, Speaker at Obesity Conference
Jose Reyes Memorial Medical Center, Philippines


Non-alcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease which may progress to non-alcoholic steatohepatitis (NASH). Currently there are no therapeutic strategies for such disease. Only lifestyle modification through diet and exercise were proven to afford some benefit in patients with NAFLD. No pharmacologic agents have so far been approved for the treatment of NAFLD or NASH. Therefore, most clinical efforts have been directed at treating the components of metabolic syndrome, namely obesity, diabetes, hypertension and dyslipidemias. Other interventions are directed at specific pathways potentially involved in the pathogenesis of NAFLD, such as insulin resistance, oxidative stress, pro- inflammatory cytokines, apoptosis, bacterial overgrowth, and angiotensin pathway. However, since the FLINT study, the largest NASH study to date, no drug has ever come close to Obeticholic acid except Ursodeoxycholic acid (UDCA). This lecture aims to show the potential of Ursodeoxycholic Acid (UDCA) as a promising therapeutic option for NAFLD. This is a 15- year Systematic Review of randomized controlled trials on the effects of Ursodeoxycholic Acid on Non-Alcoholic Fatty Liver Disease. (NAFLD). Ursodeoxycholic Acid may yet prove to be a targeted treatment for Non-Alcoholic Fatty Liver Disease.


Professor Higinio T. Mappala is a Full-time Senior Medical Specialist and Administrator at the Jose Reyes Memorial Medical Center, Manila, Philippines, A Board-certified Internist, Gastroenterologist, Endoscopist, Clinical Nutritionist and Clinical Toxicologist; has served as a University Professor and Dean of 2 Medical Schools; a highly-regarded Researcher, with more than 90 scientific papers, and more than 50 international publications, had more than 160 invites as Plenary Speaker in International Conventions since 2018 to 202, with 17 invites this year. A former Board Director of the Philippine Societies of Gastroenterology and Digestive Endoscopy; Editorial Board member, American Journal of Biomedical Science and Research; Editorial Board, AS Journal of Gastroenterology, Online Research rater of McMaster, Canada; Awardee, One of Leading Physicians in Gastroenterology 2015 and A nominee as one of the Top 100 Leading Physicians 2018 by the American Institute of Sciences. He was conferred an honorary Doctorate degree in Philosophy by the same Institute in 2019, was awarded a Lifetime Achievement Disinction as Eminent Scientists of 2022 by INSO. He is currently the Dean of Mapua University International School of Medicine.