Abstract:
Obesity is one of the most common health problems of the 21st century. The effectiveness of therapeutic methods used for obesity treatment of is insufficient, which is indicated by the increasing incidence of the disease among the world population. Patients with a specific set of biomarkers may have a higher risk of developing obesity and its health consequences. Detailed metabolic profile determination can provide insight into the molecular mechanisms underlying obesity and its comorbidities. By examining the metabolic profile, we obtain knowledge about the collection of huge number of molecules that are reagents, intermediates or end products of many enzymatic reactions. As an effective method of obesity treatment, bariatric surgery leads to favorable changes in metabolomic pathways that may affect the remission of comorbidities. The changes are associated with many biochemical compounds and pathways, such as changes in amino acids, lipids, carbohydrates, or the gut microflora. Studies also show the improvement of many clinical parameters, such as BMI, HbA1c, glucose and cholesterol levels, insulin resistance and modulation of intestinal hormones. Application of metabolomics to study effects of bariatric surgery makes it possible to obtain two groups of markers indicating the success or failure of the surgery. Obesity is associated with the development of many chronic complications. It also has an impact on the mental health and quality of life of those affected. The incidence of depression is increasing among obese people. Meanwhile, depression increases the risk of obesity. Depressed patients are more likely to engage in unhealthy behaviors such as sedentary lifestyles and improper diets. The results of our own research indicate that bariatric surgery candidates who reported unhealthy eating behavior scored higher on the Beck Depression Inventory (BDI-II). After surgery the regulation of hormone and pro-inflammatory cytokines production, can diminish symptoms of depression. On the other hand, depression may be a risk factor for weight regain after bariatric procedures. Our experience shows that patients with depressive disorders after bariatric surgery more often gain weight again and require reoperation to reduce excessive body mass. Moreover metabolomic signatures can be predictors of depression treatment.
This work was supported by funds from the Ministry of Education and Science in Poland (SKN/SP/496250/2021). Newgard CB.
Audience Take Away:
- The effect of weight reduction is on the metabolic profile.
- The influence of obesity on the associated diseases.
- The relation between depression and the success of bariatric surgery.
