Abstract:
Background: Depression is much prevalent in Women than men. Obesity and depression are leading causes of both physical and mental disability and the link between these disorders had not explored well. In view of this, in the present study we aimed to investigate the association between Body Mass Index (BMI) and depression in the trail participants of weight loss intervention.
Methods: The vital and biochemical parameters including lipid profile, homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome (MetS) components were measured for eligible screened subjects who participated in the trial of weight loss intervention at first visit. A self-reported Patient Health Questionnaire (PHQ-9) scale was employed to evaluate the depression among the participants.
Results: Obesity was associated with significant increases in depression (OR=13.01, 95% CI 4.40 to 38.49) as compared to overweight subjects. Female subjects with OB had a greater risk for depression of (β: 3.725, OR: 42.62, 95%CI: 5.74-316.3 and P=0.000) then male subjects (β: 1.922, OR: 6.83, 95%CI: 1.8-26 and P=0.005) and it was statistically significant. There was no associations were found between other models (Insulin Resistance and Metabolic syndrome components) and depression in both genders (P<0.05).
Conclusion: As women are much concerned of their physical appearance, they are psychologically much depressed. The odds of depression were more in obese women than overweight subjects. The other factors including metabolic syndrome and insulin resistance are not contributing to any form of the depression.
