Abstract:
Objective: To compare the association between hypertension with hyperuricemia (HTN-HUA)with four non-insulin-based insulin resistance indicators, including the product of glucose and triglycerides (TyG index), TyG index with BMI (TyG-BMI), the ratio of triglycerides divided by HDL (TG/HDL ratio), and a novel non-insulin-based fasting score (METS-IR).
Methods: Data from a cross-sectional epidemiological study enrolling a sample representative for Shanghai, China population aged ≥65 years, were used to calculate the four indexes. The association with HTN-HUA was examined with binomial and multinomial logistic regression.
Results: A total of 4,352 participants were included, including 93 patients with hyperuricemia, 2,875 with hypertension, and 587 with hypertension combined with hyperuricemia. Multiple-logistic regression showed that TyG index, TyG-BMI, TG/HDL, HOMA-IR were all significantly correlated with hyperuricemia, hypertension and HTN-HUA. Compared with the lowest quartile, the ORs of the highest quartile of the four indicators for HTN-HUA were TyG index:4.977 (95%CI: 3.540-6.997), TyG-BMI: 10.037 (95%CI: 7.041-14.372), TG/HDL: 7.055 (95%CI: 4.972-10.099), METS-IR: 9.668 (95%CI: 6.739-13.870), respectively. TyG-BMI and METS-IR had significant discriminative ability for HTN-HUA and the AUC values were 0.716 (0.698-0.743) and 0.726 (0.700-0.753).
Conclusion: Our study suggested that TyG index, TyG-BMI, TG/HDL, HOMA-IR had a more significant correlation with HTN-HUA risk than that with HUA or HTN, and TyG-BMI and METS-IR had significant discriminative abilities for HTN-HUA
